Nicotine products have undergone numerous developments in the last half a century. Many alternatives to traditional combustible tobacco products have been introduced to consumers, most of which were developed to reduce harms associated with traditional products. As these products become increasingly popular with consumers, it is important to continuously assess their efficacy and safety with the goal of minimising harm. In this webinar, we will present our approach to objectively and methodologically identifying and analysing the best available evidence. We will explore what the current evidence tells us about the relative harms of the full spectrum of nicotine products, from combustible cigarettes to nicotine replacement therapies. Drawing on other examples of harm reduction, we will discuss the importance of taking a pragmatic approach to public health issues to obtain better outcomes.